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Academic Article
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HIV-1 infection induces a selective reduction in STAT5 protein expression.
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Academic Article
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Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation.
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Academic Article
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Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways.
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Academic Article
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JAK3, STAT, and MAPK signaling pathways as novel molecular targets for the tyrphostin AG-490 regulation of IL-2-mediated T cell response.
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Academic Article
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Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
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Academic Article
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Genome wide mapping reveals PDE4B as an IL-2 induced STAT5 target gene in activated human PBMCs and lymphoid cancer cells.
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Academic Article
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Forskolin-inducible cAMP pathway negatively regulates T-cell proliferation by uncoupling the interleukin-2 receptor complex.
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Academic Article
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Interleukin-2 Receptor ? Thr-450 Phosphorylation Is a Positive Regulator for Receptor Complex Stability and Activation of Signaling Molecules.
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Academic Article
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Isoproterenol-induced beta-2 adrenergic receptor activation negatively regulates interleukin-2 signaling.
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Academic Article
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Prolactin stimulates serine/tyrosine phosphorylation and formation of heterocomplexes of multiple Stat5 isoforms in Nb2 lymphocytes.
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Academic Article
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Differential control of the phosphorylation state of proline-juxtaposed serine residues Ser725 of Stat5a and Ser730 of Stat5b in prolactin-sensitive cells.
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Academic Article
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Concomitant inhibition of Janus kinase 3 and calcineurin-dependent signaling pathways synergistically prolongs the survival of rat heart allografts.
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Academic Article
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The role of Stat5 in the induction of regulatory T cells in transplantation tolerance.
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Academic Article
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Selective inhibitor of Janus tyrosine kinase 3, PNU156804, prolongs allograft survival and acts synergistically with cyclosporine but additively with rapamycin.
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Academic Article
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Specific inhibition of Stat5a/b promotes apoptosis of IL-2-responsive primary and tumor-derived lymphoid cells.
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Academic Article
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The role of IL-2 in allograft rejection--a lesson learned from experimental work.
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Academic Article
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Functional uncoupling of the Janus kinase 3-Stat5 pathway in malignant growth of human T cell leukemia virus type 1-transformed human T cells.
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Academic Article
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Role of serine phosphorylation of Stat5a in prolactin-stimulated beta-casein gene expression.
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Academic Article
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Interleukin-2 family cytokines stimulate phosphorylation of the Pro-Ser-Pro motif of Stat5 transcription factors in human T cells: resistance to suppression of multiple serine kinase pathways.
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Academic Article
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Allograft rejection requires STAT5a/b-regulated antiapoptotic activity in T cells but not B cells.
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Academic Article
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A preferential role for STAT5, not constitutively active STAT3, in promoting survival of a human lymphoid tumor.
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Academic Article
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Phosphorylation of human Jak3 at tyrosines 904 and 939 positively regulates its activity.
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Academic Article
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Prolactin recruits STAT1, STAT3 and STAT5 independent of conserved receptor tyrosines TYR402, TYR479, TYR515 and TYR580.
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Academic Article
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Transcription factor signal transducer and activator of transcription 5 promotes growth of human prostate cancer cells in vivo.
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Academic Article
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STAT5 regulation of BCL10 parallels constitutive NFkappaB activation in lymphoid tumor cells.
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Academic Article
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Coactivation of janus tyrosine kinase (Jak)1 positively modulates prolactin-Jak2 signaling in breast cancer: recruitment of ERK and signal transducer and activator of transcription (Stat)3 and enhancement of Akt and Stat5a/b pathways.
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Academic Article
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Immunocompromised tumor-bearing mice show a selective loss of STAT5a/b expression in T and B lymphocytes.
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Academic Article
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Transcription factor Stat5 synergizes with androgen receptor in prostate cancer cells.
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Concept
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STAT5 Transcription Factor
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Academic Article
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JAK3 Y841 Autophosphorylation Is Critical for STAT5B Activation, Kinase Domain Stability and Dimer Formation.
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